tert-butyl (2S)-2-(aminomethyl)morpholine-4-carboxylate
(S)-N-Boc-2-aminomethylmorpholine
CAS: 879403-42-6
Molecular Formula: C10H20N2O3
tert-butyl (2S)-2-(aminomethyl)morpholine-4-carboxylate - Names and Identifiers
tert-butyl (2S)-2-(aminomethyl)morpholine-4-carboxylate - Physico-chemical Properties
| Molecular Formula | C10H20N2O3 |
| Molar Mass | 216.28 |
| Density | 1.078 |
| Boling Point | 311℃ |
| Flash Point | 141℃ |
| Vapor Presure | 0.000589mmHg at 25°C |
| pKa | 9.37±0.29(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | 1.477 |
tert-butyl (2S)-2-(aminomethyl)morpholine-4-carboxylate - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.624 ml | 23.118 ml | 46.237 ml |
| 5 mM | 0.925 ml | 4.624 ml | 9.247 ml |
| 10 mM | 0.462 ml | 2.312 ml | 4.624 ml |
| 5 mM | 0.092 ml | 0.462 ml | 0.925 ml |
Last Update：2024-01-02 23:10:35
tert-butyl (2S)-2-(aminomethyl)morpholine-4-carboxylate - Reference Information
| application | (S)-4-N-BOC-2-aminomethylmorpholine is a pharmaceutical intermediate that can be used in laboratory research and development processes and chemical production processes. |
| preparing | step 1. (S)-2-(toluenesulfonyloxymethyl) morpholin-4-formate tert-butyl ester to (S)-2-(hydroxymethyl) morpholin-4-formate tert-butyl ester (1g) dichloromethane (50mL) is added with triethylamine (1.604mL) and 4-methylbenzene-1-sulfonyl chloride (1.097g). The mixture was stirred at ambient temperature in a nitrogen atmosphere for 72 hours. Dilute the reaction with dichloromethane (50mL) and saline (100mL). The saline layer was extracted with dichloromethane (75mL). Dry the combined organic matter with sodium sulfate, filter and concentrate. Elution was performed with a 15-65% ethyl acetate/hexane gradient, and the crude was purified on a silica gel column to provide the title compound. Step An anhydrous N,N-dimethylformamide (10mL) solution of (S)-2-(toluenoyloxymethyl) morpholin-4-formate (1.66g) and sodium azide (0.581g) was stirred at 90°C for 4 hours 2. (S)-2-(S)-2-(toluenoyloxymethyl) morpholin-4-formate tert-butyl ester. The mixture is cooled and concentrated until dry. The residue was absorbed in 5% sodium carbonate aqueous solution and extracted with dichloromethane. The organic solution was dried (MgSO4), filtered and concentrated to obtain a solid. Step (S)-4-N-BOC-2-aminomethylmorpholine was 3. to obtain the compound by hydrogenating the compound (S)-2-(azomethyl) morpholin-4-formate tert-butyl formate with 10% palladium/carbon (in methanol) at 60psi hydrogen for 24 hours, then filtering and evaporating the solvent. |
Last Update：2024-04-09 19:05:05
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CAS: 879403-42-6
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CAS: 879403-42-6
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